Publikatsioonid 2017

  • Sillaste, Gerly; Kaplinski, Lauris; Meier, Riho; Jaakma, Ülle; Eriste, Elo; Salumets, Andres (2017). A novel hypothesis for histone-to-protamine transition in Bos taurus spermatozoa. Reproduction (Cambridge, England), 153 (3), 241−251.10.1530/REP-16-0441.
  • Saare, Merli; Rekker, Kadri; Laisk-Podar, Triin; Rahmioglu, Nilufer; Zondervan, Krina; Salumets, Andres; Götte, Martin; Peters, Maire (2017). Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs. BBA Molecular Basis of Disease, 1863 (9), 2282−2292.j.bbadis.2017.06.018.
  • Murto, T; Yngve, A; Skoog Svanberg, A; Altmäe, S; Salumets, A; Wånggren, K; Stavreus-Evers, A. (2017). Compliance to the recommended use of folic acid supplements for women in Sweden is higher among those under treatment for infertility than among fertile controls and is also related to socioeconomic status and lifestyle. Food Nutr Res, 61 (1).

Publikatsioonid 2014 

  • Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D’Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A. Guidelines for the design, analysis and interpretation of ‘omics’ data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb;20(1):12-28. doi: 10.1093/humupd/dmt048. Epub 2013 Sep 29. Review. PubMed PMID: 24082038; PubMed Central PMCID: PMC3845681.
  • Ausmees K, Korrovits P, Timberg G, Erm T, Punab M, Mändar R. (2014) Semen quality in middle-aged males: associations with prostate-specific antigen and age-related prostate conditions. Human Fertility, 17: 60-66.
  • Ausmees K, Korrovits P, Timberg G, Punab M, Mändar R. (2013) Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction. Brazilian International Journal of Urology, 39: 727-740.
  • Dzirkale Z., Rumaks J., Svirskis Š., Mazina O., Allikalt A., Rinken A., Jēkabsons K., Muceniece R. and Klusa V. (2013) Lunasin induces central effects in mice. Behav. Brain Res. 256(1) 5-9. (http://dx.doi.org/10.1016/j.bbr.2013.08.002)
  • Haller-Kikkatalo K, Altmäe S, Tagoma A, Uibo R, Salumets A. Autoimmune Activation toward Embryo Implantation is Rare in Immune-Privileged Human Endometrium. Semin Reprod Med. 2014 Sep;32(5):376-84. doi: 10.1055/s-0034-1376356. Epub 2014 Jun 24. PubMed PMID: 24959819.
  • Krjutškov K, Koltšina M, Grand K, Võsa U, Sauk M, Tõnisson N, Salumets A. Tissue-specific mitochondrial heteroplasmy at position 16,093 within the same individual. Curr Genet. 2014 Feb;60(1):11-6. doi: 10.1007/s00294-013-0398-6. Epub 2013 Jul 11. PubMed PMID: 23842853; PubMed Central PMCID: PMC3895442.
  • Kullisaar T, Türk S, Kilk K, Ausmees K, Punab M, Mändar R. (2013) Increased levels of hydrogen peroxide and nitric oxide in male partners of infertile couples. Andrology 1(6): 850-8.
  • Kõks S, Reimann E, Lilleoja R, Lättekivi F, Salumets A, Reemann P, Jaakma Ü. (2014) Sequencing and annotated analysis of full genome of Holstein breed bull, Mammalian Genome. 2014 Apr 26. [Epub ahead of print]
  • Lokk K, Modhukur V, Rajashekar B, Märtens K, Mägi R, Kolde R, Koltšina M, Nilsson TK, Vilo J, Salumets A, Tõnisson N. DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biol. 2014 Apr 1;15(4):R54. [Epub ahead of print] PubMed PMID: 24690455; PubMed Central PMCID: PMC4053947.
  • Margus, H.; Padari, K.; Pooga, M. (2013) “Insights on cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy”, Advanced Drug Delivery Reviews Jul;65(8):1031-8.
  • Murto T, Skoog Svanberg A, Yngve A, Nilsson TK, Altmäe S, Wånggren K, Salumets A, Stavreus-Evers A. Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility. Reprod Biomed Online. 2014 Jun;28(6):766-72. doi: 10.1016/j.rbmo.2014.01.017. Epub 2014 Feb 25. PubMed PMID: 24745837.
  • Pae, J., and Pooga, M. (2014) Peptide-mediated delivery: an overview of pathways for efficient internalization, Therapeutic Delivery (resubmitted)
  • Pae, J., Säälik, P., Liivamägi, L., Lubenets, D., Arukuusk, P., Langel, Ü., and Pooga, M. (2014) Accumulation of cell-penetrating peptides into giant plasma membrane vesicles is controlled by cholesterol and microenvironment created by membranous proteins, Journal of Controlled Release (in press)
  • Perry JR, Hsu YH, Chasman DI, … Salumets A, … Murabito JM, Karasik D, Murray A. DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Hum Mol Genet. 2014 May 1;23(9):2490-7. doi: 10.1093/hmg/ddt620. Epub 2013 Dec 19. PubMed, PMID: 24357391; PubMed Central PMCID: PMC3976329.
  • Punab M, Kullisaar T, Mändar R. (2013) Male infertility workup needs additional testing of expressed prostatic secretion and/or post-massage urine. PLoS One, 8(12): e82776.
  • Rekker, K., Saare, M., Roost, A.M., Salumets, A., Peters, M. (2013). Circulating microRNA Profile throughout the Menstrual Cycle . PLoS ONE, 8(11), e81166
  • Rekker, K.; Saare, M.; Roost, AM.; Kubo, AL.; Zarovni, N.; Chiesi, A.; Salumets, A.; Peters, M. (2014). Comparison of serum exosome isolation methods for microRNA profiling. Clinical Biochemistry, 47(1-2), 135 – 138.
    Saare, M.; Tõnissoo, T.; Pert, R.; Meier, R.; Lulla, S.; Karis, A.; Salumets, A.; Pooga, M. (2014) “Dynamic localization of guanine nucleotide exchange factor RIC8 in mammalian oogenesis“ (under revision for Plos One).
  • Tõntson L., Kopanchuk S. and Rinken A. (2013) Biarsenical ligands bind to endogenous G-protein α-subunits and enable allosteric sensing of nucleotide binding. BMC Biochemistry 14:37. (http://doi:10.1186/1471-2091-14-37).
  • Tõntson L., Kopanchuk S. and Rinken A. (2014) Characterization of 5-HT1A receptors and their complexes with G-proteins in budded baculovirus particles using fluorescence anisotropy of Bodipy-FL-NAN-190. Neurochemistry International 67, 32-38. (http://dx.doi.org/10.1016/j.neuint.2014.01.012).
  • Türk S; Mazzoli S; Štšepetova J; Kuznetsova J; Mändar R. (2014) Coryneform bacteria in human semen: inter-assay variability in species composition detection and biofilm production ability. Microbial Ecology in Health and Disease, 25, 1 – 6.
  • Türk S; Mändar R; Mahlapuu R; Viitak A; Punab M; Kullisaar T. (2014) Male infertility: Decreased levels of selenium, zinc and antioxidants. Journal of Trace Elements in Medicine and Biology, 28(2), 179 – 185.
  • Veiksina S., Kopanchuk S. and Rinken A. (2014) Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to G protein-coupled receptors: the case of melanocortin 4 receptors. Biochimica et Biophysica Acta (BBA) – Biomembranes. 1838(1B) 372–381. (http://dx.doi.org/10.1016/j.bbamem.2013.09.015).
  • Velthut-Meikas A, Simm J, Tuuri T, Tapanainen JS, Metsis M, Salumets A. Research resource: small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes. Mol Endocrinol. 2013 Jul;27(7):1128-41. doi: 10.1210/me.2013-1058. Epub 2013 May 9. PubMed PMID: 23660593.
  • Väärtnõu, F., Pert, R.; Saare, M.; Tõnissoo, T.; Meier, R.; Lulla, S.; Karis, A.; Salumets, A.; Pooga, M. (2014) “Guanine nucleotide exchange factor RIC8 in mammalian spermatogenesis and sperm activation“ (submitted to Human Reproduction).

Publikatsioonid 2013

 

  • M. Lamp, M. Saare, Ü. Kadastik, H. Karro, A. Salumets, R. Uibo, M. Peters. Survivin promoter polymorphisms and autoantibodies in endometriosis. Journal of Reproductive Immunology (2012) 96, 95 – 100.
  • Velthut-Meikas A; Simm J; Tuuri T; Tapanainen JS; Metsis M; Salumets A. (2013). Research Resource: Small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes. Molecular Endocrinology (In Press).
  • Velthut A; Zilmer M; Zilmer K; Kaart T; Karro H; Salumets A. (2013). Elevated blood plasma antioxidant status is favourable for achieving IVF/ICSI pregnancy. Reprod Biomed Online. 2013 Apr;26(4):345-52.
  • Perry JR; Corre T; Esko T; … Salumets A; … Vollenweider P, Toniolo D, Murray A. (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013 Apr 1;22(7):1465-72.
  • Köttgen A; Albrecht E; Teumer A; … Salumets A; … Caulfield M; Bochud M; Gieger C. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013 Feb;45(2):145-54.
  • Drell T, Lillsaar T, Tummeleht L, Simm J, Aaspõllu A, Väin E, Saarma I, Salumets A, Donders GG, Metsis M. (2013). Characterization of the vaginal micro- and mycobiome in asymptomatic reproductive-age Estonian women. PLoS One. 2013;8(1):e54379.
  • Margus, H.; Padari, K.; Pooga, M. (2013) “Insights on cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy”, Advanced Drug Delivery Reviews (Apr 24. doi:pii: S0169-409X(13)00098-7. 10.1016/j.addr.2013.04.013).
  • Juks, C., and Pooga, M. (2013) Scavenger receptors in the cellular uptake of nucleic acids, Chemistry Today (Chimica Oggi) 31(2), 12-14 (Suppl. Oligos and Peptides)
  • Väärtnõu, F., Pert, R.; Saare, M.; Tõnissoo, T.; Meier, R.; Lulla, S.; Karis, A.; Salumets, A.; Pooga, M. (2013) “Guanine nucleotide exchange factor RIC8 in mammalian spermatogenesis and sperm activation“ (manuscript for Biol. Reproduct.).
  • Saare, M.; Tõnissoo, T.; Pert, R.; Meier, R.; Lulla, S.; Karis, A.; Salumets, A.; Pooga, M. (2013) “Dynamic localization of guanine nucleotide exchange factor RIC8 in mammalian oogenesis“ (resubmitted to Histochemistry and Cell Biology).
  • Tamm-Rosenstein, Karin; Simm, Jaak; Suhorutšenko, Marina; Salumets, Andres; Metsis, Madis. (2013). Changes in the Transcriptome of the Human Endometrial Ishikawa Cancer Cell Line Induced by Estrogen, Progesterone, Tamoxifen, and Mifepristone (RU486) as Detected by RNA-Sequencing . PLoS ONE, 8, e68907
  • Uibo, R.; Salumets, A.; Faure, G. (2012). Immunological aspects of human reproduction. Clin Dev Immunol 408329: 1-2.
  • Sarapik A, Velthut A, Haller-Kikkatalo K, Faure GC, Béné MC, de Carvalho Bittencourt M, Massin F, Uibo R, Salumets A. (2012). Follicular proinflammatory cytokines and chemokines as markers of IVF success. Clin Dev Immunol. 2012:606459.
  • Reinart-Okugbeni R., Ausmees K., Kriis K., Werner F., Rinken A. and Kanger T. (2012) Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands. Eur. J. Med. Chem. 55, 255-261. (DOI: 10.1016/j.ejmech.2012.07.025).
  • Mazina O., Reinart-Okugbeni R., Kopanchuk S. and Rinken A. (2012) BacMam system for FRET based cAMP sensor expression in studies of melanocortin MC1 receptor activation J. Biomol. Screening 17(8), 1096 – 1101. (doi: 10.1177/1087057112449862).
  • Tõntson L., Babina A., Võsumaa T., Kopanchuk S. and Rinken A. (2012) Characterization of heterotrimeric nucleotide-depleted Gαi-proteins by Bodipy-FL-GTPγS fluorescence anisotropy. Arch. Biochem. Biophys. 524(2), 93-98 (doi: 10.1016/j.abb.2012.05.017)
  • Reinart-Okugbenin, R., Vonk, A., Uustare A., Gyulai Z., Sipos, A. and Rinken, A. (2013) 1-Substituted Apomorphines as Potent Dopamine Agonists. Bioorg. Med. Chem. 21(14), 4143-4150. (http://dx.doi.org/10.1016/j.bmc.2013.05.014)
  • Pärn P., Nõmm, M., Plaas, M., Jaakma, Ü, Kõks S. Effects of culture conditions and gene transfection on the development of bovine SCNT embryos. Reproduction, Fertility and Development, 2013, vol 25, 1, 172.
  • Ausmees K, Mändar R, Korrovits P, Źarkovski M, Timberg G, Punab M. (2013) Reproductive function in middle-aged males: healthy men versus male partners of infertile couples. Andrologia, in press (doi: 10.1111/and.12055).
  • Mändar R, Kullisaar T, Borovkova N, Punab M. (2013) Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples. Andrology, 1(3): 464-8.
  • Mändar R. (2013) Microbiota of male genital tract: Impact on the health of man and his partner. Pharmacological Research, 69: 32-41.
  • Ausmees, K.; Korrovits, P; Timberg, G.; Punab, M.; Mändar, R. (2013). Semen quality and associated reproductive indicators in middle-aged males: the role of non-malignant prostate conditions and genital tract inflammation. World Journal of Urology, in press.

Publikatsioonid 2012

 

  • Merli Saare, Deniss Sõritsa, Kadri Vaidla, Priit Palta, Maido Remm, Martti Laan, Helle Karro, Andrei Sõritsa, Andres Salumets, Thomas D´Hooghe ja Maire Peters. „No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis,“ Human Reproduction 2012 Apr 3. [Epub ahead of print]
  • Merli Saare, Merit Lamp, Ülle Kadastik, Helle Karro, Triin Laisk, Andres Salumets, Kadri Matt, Maire Peters „Endometrioos – anamneesist diagnoosini“. Eesti Arst, 2011; 90(7):321–326
  • Altmäe S, Reimand J, Hovatta O, Zhang P, Kere J, Laisk T, Saare M, Peters M, Vilo J, Stavreus-Evers A, Salumets A. “Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks.” Mol Endocrinol. 2012 Jan;26(1):203-17. Epub 2011 Nov 10.
  • Stolk L, Perry JR, … Salumets A, … Visser JA, Lunetta KL. “Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways”. Nature Genetics. 2012 Jan 22;44(3):260-8.
  • Säälik, P., Niinep, A., Hansen, M., Pae, J., Lubenets, D., Langel, Ü., and Pooga ,M. (2011) “Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles”, Journal of Controlled Release 153,117-25
  • Tamm, K.; Suhorutšenko, M.; Talving, E.; Kaljas, A.; Metsis, M. “Suguhormoonide östradiooli ja progesterooni koespetsiifiline roll inimese endomeetriumis ja rinnanäärmes”, Eesti Arst, 2012-4.
  • Haller-Kikkatalo K, Salumets A, Uibo. “Autoimmune reactions in female Infertility – antibodies to follicule stimulating hormone”. Clin Dev Immunol 2012.
  • Tõntson L., Babina A., Võsumaa T., Kopanchuk S. and Rinken A. (2012) Characterization of heterotrimeric nucleotide-depleted Gαi-proteins by Bodipy-FL-GTPγS fluorescence anisotropy. Arch. Biochem. Biophys. 524(2), 93-98 (doi: 10.1016/j.abb.2012.05.017)
  • Mazina O., Reinart-Okugbeni R., Kopanchuk S. and Rinken A. (2012) BacMam system for FRET based cAMP sensor expression in studies of melanocortin MC1 receptor activation J. Biomol. Screening (doi: 10.1177/1087057112449862).
  • Korrovits P, Ausmees K, Mändar R, Punab M. “Seminal interleukin-6 and serum prostate-specific antigen as possible predictive biomarkers in asymptomatic inflammatory prostatitis.” Urology 2011, Aug;78(2):442-6.

Publikatisoonid 2011

 

• Altmäe S, Reimand J, Hovatta O, Zhang P, Kere J, Laisk T, Saare M, Peters M, Vilo J, Stavreus-Evers A, Salumets A. (2012). Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks. Mol Endocrinol. 2012 Jan;26(1):203-17.
• Altmäe S, Salumets A, Bjuresten K, Kallak TK, Wånggren K, Landgren BM, Hovatta O, Stavreus-Evers A. (2011). Tissue Factor and Tissue Factor Pathway Inhibitors TFPI and TFPI2 in Human Secretory Endometrium – Possible Link to Female Infertility. Reproductive Sciences, 18(7), 666-678.
• Stolk L, Perry JRB, Chasman DI, … …, Salumets A, … …, Murabito JM, Visser JA, Lunetta KL. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 2012 Jan 22.
• Haller-Kikkatalo K, Sarapik A, Faure GC, Béné MC, Massin F, Salumets A, Uibo R. (2012). Serum sTREM-1 (Soluble Triggering Receptor Expressed on Myeloid Cells-1) Associates Negatively with Embryo Quality in Infertility Patients. Am J Reprod Immunol, 2012 Jan 9.
• Sarapik A, Velthut A, Haller-Kikkatalo K, Faure GC, Béné MC, Massin F, Uibo R, Salumets A. (2012). Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success. Clin Dev Immunol, Epub 2011 Oct 5.
• Haller-Kikkatalo K, Salumets A, Uibo R. (2012). Review on autoimmune reactions in female infertility: antibodies to follicle stimulating hormone. Clin Dev Immunol, Epub 2011 Oct 5.
• Altmäe S, Hovatta O, Stavreus-Evers A, Salumets A. (2011). Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Hum Reprod Update. 2011 Nov-Dec;17(6):813-28.
• Laisk T, Peters M, Salumets A. (2011). Mannose-binding lectin genotypes: potential role in tubal damage and adverse IVF outcome. J Reprod Immunol. 2011 Dec;92(1-2):62-7.
• Säälik, P., Niinep, A., Hansen, M., Pae, J., Lubenets, D., Langel, Ü., and Pooga ,M. (2011) Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles, Journal of Controlled Release 153,117-25.
• Korrovits P, Ausmees K, Mändar R, Punab M. Seminal interleukin-6 and serum prostate-specific antigen as possible predictive biomarkers in asymptomatic inflammatory prostatitis. Urology 2011, Aug;78(2):442-6.
• Borovkova N, Korrovits P, Ausmees K, Türk S, Jõers K, Punab M, Mändar R. Influence of sexual intercourse on genital tract microbiota in infertile couples. Anaerobe. 2011 Dec;17(6):414-8.

Publikatsioonid 2010

 

• Sarapik A, Haller-Kikkatalo K, Utt M, Teesalu K, Salumets A, Uibo R. Serum anti-endometrial antibodies in infertile women – potential risk factor for implantation failure. Am J Reprod Immunol. 2010 May;63(5):349-57. Epub 2010 Feb 3.
• M. Lamp, M. Peters, E. Reinmaa, K. Haller-Kikkatalo, T. Kaart, Ü. Kadastik, H. Karro, A. Metspalu, A. Salumets. Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis. Gynecological Endocrinology, 2010.
• Lamp M, Saare M, Laisk T, Karro H, Kadastik Ü, Metspalu A, Peters M, Salumets A. Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010.
• Kõks S, Velthut A, Sarapik A, Altmäe S, Reinmaa E, Schalkwyk LC, Fernandes C, Lad HV, Soomets U, Jaakma U, Salumets A. The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles. Mol Hum Reprod. 2010 Apr;16(4):229-40. Epub 2009 Nov 20.
• Saare M, Lamp M, Kaart T, Karro H, Kadastik U, Metspalu A, Peters M, Salumets A. Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis. Fertil Steril. 2010 Jan 23. [Epub ahead of print].
• Laisk T, Peters M, Saare M, Haller-Kikkatalo K, Karro H, Salumets A. Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility. J Reprod Immunol. 2010 Jul 1. [Epub ahead of print].
• Laanpere M, Altmäe S, Stavreus-Evers A, Nilsson TK, Yngve A, Salumets A. Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. Nutr Rev. 2010 Feb;68(2):99-113.
• Altmäe S, Martínez-Conejero JA, Salumets A, Simón C, Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod. 2010 Mar;16(3):178-87.
• Altmäe S, Stavreus-Evers A, Ruiz JR, Laanpere M, Syvänen T, Yngve A, Salumets A, Nilsson TK. Variations in folate pathway genes are associated with unexplained female infertility. Fertil Steril. 2010 Jun;94(1):130-7. Epub 2009 Mar 26.
• Lend AK, Belousova A, Haller-Kikkatalo K, Punab M, Poolamets O, Peters M, Salumets A. Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis. Syst Biol Reprod Med. 2010 Feb;56(1):84-90.
• Veiksina S., Kopanchuk S. and Rinken A. (2010) Fluorescence anisotropy assays for pharmacological characterization of ligand binding dynamics to melanocortin 4 receptors. Anal. Biochem. 402(1), 32-39.

Publikatsioonid 2009

 

• Peters M, Saare M, Kaart T, Haller-Kikkatalo K, Lend AK, Punab M, Metspalu A, Salumets A. Analysis of Polymorphisms in the SRD5A2 Gene and Semen Parameters in Estonian Men. J Androl. 2009 Nov 19.
• Tamm K, Rõõm M, Salumets A, Metsis M. Genes targeted by the estrogen and progesterone receptors in the human endometrial cell lines HEC1A and RL95-2. Reprod Biol Endocrinol. 2009 Dec 24;7.