Mouse models for assessing gametogenesis and implantation
The present sub-project has 2 major aims:
1) to design and optimise in vitro mouse model for characterisation of the trophoblast-endometrial adhesion using various culture conditions and implantation-specific gene activity silencing and
2) to establish a mouse germline specific gene ablation system by applying Vasa-Cre system to knockout Ric-8 gene in primordial germ cells of both sexes.
Project head: Prof. Margus Pooga